Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans
J. Clin. Invest. 116:6 doi:10.1172/JCI27890 [Go to this article.]

Figure 5
GlcCer is required for growth of C. neoformans cells in 5% CO₂ at pH 7.4. C. neoformans WT, Δgcs1, and Δgcs1 + GCS1 strains were grown in DMEM medium at 37°C in 5% CO₂ at pH 7.4 (A) and pH 4.0 (B).

*P < 0.001, Δgcs1 versus WT. (C) Succession of biological events characterizing a yeast cell cycle.