Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria
J. Clin. Invest. Masaru Yoshida, et al. 116:2142 doi:10.1172/JCI27821 [
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Figure 3
Susceptibility to
C. rodentium
infection in the presence of FcRn.
(
A and
B) Susceptibility to infection with 1 × 10
9 CFU of
C. rodentium in FcRn
–/– BALB/c mice. (
A) Body weight changes in FcRn
–/– and FcRn
+/– mice with
C. rodentium infection. (
B) CFU of
C. rodentium in feces of FcRn
–/– and FcRn
+/– mice 21 days after infection. Mean ± SD are shown for each group (
n = 6). (
C–
E) Susceptibility to infection with
C. rodentium in FcRn
–/– C57BL/6 mice. Survival rate (
C) and body weight changes (
D) in FcRn
–/– and FcRn
+/– mice with
C. rodentium infection. (
E) CFU of
C. rodentium in feces of FcRn
–/– and FcRn
–/+ mice 21 days after infection. Mean ± SD are shown for each group (
n = 8). (
F) Immunohistochemical analysis of the colon to detect intimin in mice with
C. rodentium infection. Colonic tissues were collected at day 7 from selected mice on a C57BL/6 background. Sections were stained for intimin using a polyclonal rabbit anti–
C. rodentium intimin antibody (red) and nuclei (blue) and were examined by confocal microscopy. Magnification, ×400. Macroscopic findings (
G) and the length of colon (
H) in FcRn
–/– and FcRn
+/– C57BL/6 mice, uninfected or infected with
C. rodentium, at 21 days after infection. (
I) Histological findings of colon in FcRn
–/– and littermate FcRn
+/– C57BL/6 mice with or without
C. rodentium infection (21 days after infection). Magnification, ×100. (
J) Histological score of colonic tissue in the mice with or without
C. rodentium infection at day 21. *
P < 0.05.