Corrigendum

Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease

Olga V. Nikolskaia, Ana Paula C. de A. Lima, Yuri V. Kim, John D. Lonsdale-Eccles, Toshihide Fukuma, Julio Scharfstein and Dennis J. Grab

Original citation: J. Clin. Invest.116:2739–2747 (2006). doi:10.1172/JCI27798.

Citation for this erratum: J. Clin. Invest.118:1974 (2008). doi:10.1172/JCI27798C1.

The Trypanosoma species used in this study included a clinically relevant human CSF isolate and bloodstream form (BSF) from a patient with sleeping sickness. A cloned derivative from this parasite termed “IL1852” was originally identified as a T.b. gambiense and was denoted accordingly in the manuscript.

However, the authors recently discovered that IL1852 contains the SRA gene, a characteristic only encountered in T.b. rhodesiense (1). Therefore, because ILRI T.b. gambiense IL2343, a clone derivative of STIB386AA that was derived from TH144/78E(020), was later reclassified as a T.b. rhodesiense (2), the authors have reclassified IL1852 as a T.b. rhodesiense to maintain accuracy.

While the reclassification affects certain aspects of the conclusions of this work, it does not invalidate the key finding of a difference in the BBB traversal between human and animal trypanosomes that correlates with the greater incidence of CNS infection in human compared with animal parasites.

References

1. Welburn, S.C., et al. 1990. Identification of human-infective trypanosomes in animal reservoir of sleeping sickness in Uganda by means of serum-resistance–associated (SRA) gene. Lancet. 358:2017-2019.
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2. Hide, G., Cattand, P., LeRay, D., Barry, J.D., Tait, A. 1990. The identification of Trypanosoma brucei subspecies using repetitive DNA sequences. Mol. Biochem. Parasitol. 39:213-225.
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