CXCR2 ligands and G-CSF mediate PKCα-induced intraepidermal inflammation
J. Clin. Invest. Christophe Cataisson, et al. 116:2757 doi:10.1172/JCI27514 [
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Figure 7PKCα inhibition attenuates abnormal levels of basal and induced CXCL8 in keratinocytes from psoriatic patients. Real-time PCR analysis of CXCL8 mRNA expression in normal and psoriatic keratinocytes from lesional skin biopsy samples from psoriatic patients (Psoriatic 1–3) or normal skin of healthy controls treated as described in Methods. “Normal” is representative of cultured keratinocytes from 3 healthy controls. Bars represent the mean value of triplicate determinations from a single patient. Results are expressed as fold increase in expression compared with that in untreated normal keratinocytes.
