CXCR2 ligands and G-CSF mediate PKCα-induced intraepidermal inflammation
J. Clin. Invest. Christophe Cataisson, et al. 116:2757 doi:10.1172/JCI27514 [
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Figure 6Prevention of KC and G-CSF expression by the classical PKC inhibitor Gö 6976. Gö 6976 was applied once topically just prior to TPA treatment. KC and G-CSF expression was quantified in skin extract (
A and
B, respectively), and levels circulating G-CSF (
C) were determined in serum. The control group received the same volume of the solvent. Bars represent the mean ± SEM for 4 animals, and results are representative of 2 independent experiments. *
P < 0.05 versus no TPA treatment.