KSHV targets multiple leukocyte lineages during long-term productive infection in NOD/SCID mice
J. Clin. Invest. Christopher H. Parsons, et al. 116:1963 doi:10.1172/JCI27249 [Go to this article.]

Figure 6
KSHV-specific human antibody production in NOD/SCID-hu mice inoculated with KSHV. (A) Compared with unimplanted mice (U), sera from NOD/SCID mice receiving human tissue implants (I) contained detectable amounts of total human IgG. (B–E). Serum (1:80) from an implanted and KSHV-injected mouse probed with either anti-human (B) or anti-mouse (C) secondary antibodies. Serum from a human KSHV–infected patient (1:640) (D) or rabbit polyclonal anti-LANA antiserum (1:40) (E) followed by anti-human or anti-rabbit secondary antibodies conjugated to Texas Red, respectively. Original magnification, ×60.