KSHV targets multiple leukocyte lineages during long-term productive infection in NOD/SCID mice
J. Clin. Invest. Christopher H. Parsons, et al. 116:1963 doi:10.1172/JCI27249 [
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Figure 3Thin section EM of NOD/SCID-hu spleens demonstrated virion production 3 months after infection with KSHV. (
A) Angular C capsid (arrow) within cytoplasmic vesicle. (
B) A capsids. (
C) Cytoplasmic virion. (
D) Cytoplasmic virion likely sectioned asymmetrically, allowing good visualization of angular capsid. (
E) Virion within cytoplasmic vesicle likely during egress toward plasma membrane (pm). (
F) Released virion in extracellular space(es). (
G–
I) Identical to images
D–
F, respectively, but with an additional ×2.5 magnification to reveal subviral structural components. t, tegument; c, capsid; gp, glycoproteins; e, envelope; v, vesicle; d, viral DNA. Original magnification, ×28,000. Scale bars, 0.2 μm.
