Meinrad Gawaz, Harald Langer, Andreas E. May
J Clin Invest.
2005;
115(12):3378–3384
doi:10.1172/JCI27196
This article Copyright © 2005, The American Society for Clinical Investigation
Abstract
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latelets represent an important linkage between inflammation, thrombosis, and atherogenesis. Inflammation is characterized by interactions among platelets, leukocytes, and ECs. These interactions trigger autocrine and paracrine activation processes that lead to leukocyte recruitment into the vascular wall. Platelet-induced chronic inflammatory processes at the vascular wall result in development of atherosclerotic lesions and atherothrombosis. This Review highlights the molecular machinery and inflammatory pathways used by platelets to initiate and accelerate atherothrombosis.
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