Platelet-derived or soluble CD154 induces vascularized allograft rejection independent
of cell-bound CD154
J. Clin. Invest. He Xu, et al. 116:769 doi:10.1172/JCI27155 [
Go to this article.]
Figure 5When infused 30 days after surgery, soluble rCD154 induces rejection but platelets do not. (
A) CD154KO animals that received rCD154 trimers 30 days after transplantation promptly rejected their allografts (
n = 5;
P = 0.008 versus untreated animals). Animals receiving platelet transfusions 30 days after transplantation did not reject (
n = 5). (
B) CD154-KO recipients that received human platelet transfusions on day 30 were euthanized 30 days after infusion and showed no evidence of rejection. Magnification, ×20. (
C) Those receiving trimers had histologically typical rejection. Magnification, ×40.
