Platelet-derived or soluble CD154 induces vascularized allograft rejection independent
of cell-bound CD154
J. Clin. Invest. He Xu, et al. 116:769 doi:10.1172/JCI27155 [
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Figure 1Human CD154 (hCD154) induces cellular proliferation in mice that is blocked by human CD154–specific but not murine CD154–specific antibodies. Shown are results from MLR using B6-CD154-KO responders (B6.129S2-Tnfsf5) versus BALB/c stimulators with or without human rCD154 trimers (50 μg/ml) and/or the human- or murine-specific CD154 mAbs. KO lymphocytes respond poorly in MLRs, and this response is greatly augmented by the addition of human CD154 trimers. This proliferation is specifically blocked by the human-specific antibody 5c8 but not by the murine-specific antibody MR-1 or isotype controls.
