Prelamin A and lamin A appear to be dispensable in the nuclear lamina
J. Clin. Invest. Loren G. Fong, et al. 116:743 doi:10.1172/JCI27125 [Go to this article.]

Figure 7
Lmna^+/+ and Lmna^LCO/+ cells exhibit greater nuclear deformation by biaxial strain than do wild-type cells. Biaxial strain was applied to wild-type, Lmna^LCO/+, Lmna^+/+, and Lmna –/ – cells, and the extent of nuclear deformation was measured and expressed as a ratio of nuclear strain to membrane strain (Normalized nuclear strain). Lmna^LCO/+ and Lmna^+/+ cells exhibited a small but statistically significant increase in normalized nuclear strain compared with wild-type cells (P < 0.001, unpaired t test with Welch’s correction).