Prelamin A and lamin A appear to be dispensable in the nuclear lamina
J. Clin. Invest. Loren G. Fong, et al. 116:743 doi:10.1172/JCI27125 [Go to this article.]

Figure 6
Analysis of nuclear shape in wild-type, Lmna –/ –, Lmna^LCO/ –, Lmna^LCO/+, and Lmna^+/+ fibroblasts. The nuclear envelope of cells was visualized with antibodies against lamin B or LAP2, and the number of cells with misshapen nuclei was scored by 2 trained observers blinded to genotype. Bars show the mean frequency of misshapen nuclei; the number of misshapen nuclei and the total number of nuclei examined are shown within each bar. The graph summarizes data for 3 independent experiments (filled circles). Both Lmna^LCO/+ and Lmna^+/+ cells had a slight but statistically significant increase in number of misshapen nuclei compared with wild-type cells (P < 0.007, χ² test).