Prelamin A and lamin A appear to be dispensable in the nuclear lamina
J. Clin. Invest. Loren G. Fong, et al. 116:743 doi:10.1172/JCI27125 [
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Figure 3Bone abnormalities are absent in
Lmna+/+ and
Zmpste24 –/ –Lmna+/+ mice. Surface renderings of μCT scans of the spine and skull are shown for 28-week-old wild-type (
A,
E, and
I),
Lmna+/+ (
B,
F, and
J),
Zmpste24 –/ – (
C,
G, and
K) and
Zmpste24 –/ –Lmna+/+ mice (
D,
H, and
L). (
A–
D) Thoracic spine. In the
Zmpste24 –/ – mouse (
C), callus around a rib fracture is indicated by a white arrow. Rib fractures were absent in
Lmna+/+ and
Zmpste24 –/ –Lmna+/+ mice. (
E–
H) Top view of skulls.
Zmpste24 –/ – mice showed a loss of the zigzag appearance of the cranial sutures (black arrow) and an osteolytic lesion of the zygomatic arch (red arrow). Wild-type,
Lmna+/+, and
Zmpste24 –/ –Lmna+/+ skulls were normal. (
I–
L) Lateral view of skulls.
Zmpste24 –/ – mice exhibited a small mandible and an osteolytic lesion in the posterior portion of the zygomatic arch (yellow arrow). These abnormalities were absent in wild-type,
Lmna+/+, and
Zmpste24 –/ –Lmna+/+ skulls.
