Prelamin A and lamin A appear to be dispensable in the nuclear lamina
J. Clin. Invest. Loren G. Fong, et al. 116:743 doi:10.1172/JCI27125 [
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Figure 2Weight gain and grip strength is normal in
Lmna+/+ and
LmnaLCO/ – mice. (
A) Female
LmnaLCO/ – (
n = 9) and
Lmna+/+ mice (
n = 13) exhibit normal growth, indistinguishable from wild-type mice (
n = 9). Similar results were obtained with male mice (not shown). The growth rate for female
Lmna –/ – mice (
n = 7) is shown for comparison. (
B) Grip strength in 3- to 4-week-old and 16- to 17-week-old mice as judged by the length of time that they were able to hang upside-down from a grid (
14). For 3- to 4-week-old mice,
n = 7 (wild-type), 13 (
Lmna –/ –), 9 (
LmnaLCO/ –), and 11 (
Lmna+/+). For 16-week-old mice,
n = 3 (wild-type), 6 (
LmnaLCO/ –), and 7 (
Lmna+/+). Grip strength in
Lmna –/ – mice at 16 weeks of age was not determined (ND) because the mice did not survive to this age. NS, wild type versus
Lmna+/+.
