Enhanced PIP₃ signaling in POMC neurons causes K_ATP channel activation and leads to diet-sensitive obesity
J. Clin. Invest. Leona Plum, et al. 116:1886 doi:10.1172/JCI27123 [Go to this article.]

Figure 3
Phenotypic characteristics of control (open symbols; white bars) and PPKO (filled symbols; black bars) male mice under different dietary conditions with respect to energy homeostasis. (A)Average body weights of male mice on ND (diamonds) or HFD (squares) (n = 4–93). (B)Average body length of males on ND (n = 13–22). (C)BMI of male ND-fed control and PPKO mice (n = 13–22). (D)Absolute and relative (corrected for body weight) epididymal fat pad weights of ND-fed control and PPKO males (n = 15–22). (E)Body fat content of male ND-fed PPKO and control males as measured by dual-energy X-ray absorptiometry (n = 10–16). (F)Daily caloric intake of ND-fed control and PPKO males at the age of 10–13 weeks (n = 6 per genotype). (G)Oxygen consumption (VO₂) of male body weight–matched ND-fed mice at the age of 12 weeks (n = 4 per genotype). (H)Locomotor activity of body weight–matched ND-fed males at the age of 12 weeks (n = 4 per genotype). Unless otherwise indicated, data were collected at 20 weeks of age. Values are mean ± SEM. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001 versus control.