Cholinergic dysfunction in a mouse model
of Alzheimer disease is reversed
by an anti-Aβ antibody
J. Clin. Invest. Kelly R. Bales, et al. 116:825 doi:10.1172/JCI27120 [
Go to this article.]
Figure 6Habituation learning in a novel open field in PDAPP mice is normalized after treatment with m266. (
A) PDAPP transgenic mice exhibited increased locomotor activity, which was reduced following treatment with the anti-Aβ antibody m266 (500 μg i.p.) but not following treatment with the anti-Aβ antibody 3D6 (500 μg i.p.). (
B) Accumulated locomotor activity per 60-minute session. ***
P < 0.001.
n = 20 mice per group, 4–6 months of age.
