Cholinergic dysfunction in a mouse model
of Alzheimer disease is reversed
by an anti-Aβ antibody
J. Clin. Invest. Kelly R. Bales, et al. 116:825 doi:10.1172/JCI27120 [
Go to this article.]
Figure 1Hippocampal ACh release and tissue levels are reduced in PDAPP transgenic mice. (
A) Basal levels of hippocampal ACh release measured by in vivo microdialysis from WT and PDAPP transgenic mice (
n = 7–10 mice per group, 4–6 months of age). (
B and
C) Tissue levels of ACh from the hippocampus (
B) and cortex (
C) of PDAPP and WT mice (
n = 6 mice per group). *
P < 0.05 versus WT.
