Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II–deficient mice
J. Clin. Invest. Ken-ichi Aihara, et al. 117:1514 doi:10.1172/JCI27095 [
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Figure 9Effects of HCII deficiency and of human purified HCII supplementation on wire-injured vascular remodeling. (
A) Representative histological findings for wire-injured femoral arteries. Micrographs of cross sections of wire-injured arteries stained with Elastica–van Gieson on day 28 in
HCII+/+ mice treated with vehicle and in
HCII+/– mice treated with vehicle alone or human purified HCII protein are shown. (
B) Quantitative comparison of arterial intimal area, medial area, adventitial area, intima/media ratio, and adventitia/media ratio in wire-injured
HCII+/+ mice treated with vehicle (white bars) and
HCII+/– mice treated with vehicle (black bars) or human purified HCII protein (gray bars). Values are expressed as mean ± SEM. *
P < 0.05.
n = 8–10 in each group.
