Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II–deficient mice
J. Clin. Invest. Ken-ichi Aihara, et al. 117:1514 doi:10.1172/JCI27095 [
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Figure 7Expression of PAR-1, inflammatory cytokines and chemokines, and vascular remodeling–related transcription factors with and without cuff injury in
HCII+/+ and
HCII+/– mice.
(
A) Immunohistochemical staining of PAR-1 with and without cuff injury in
HCII+/+ and
HCII+/– mice. (
B) Gene expression of vascular remodeling factors at the vascular wall with and without cuff injury in
HCII+/+ (white bars) and
HCII+/– mice (black bars). Real-time PCR analyses of
Il1b,
Il6,
Mcp1,
Egr1, and
Klf5 were performed in
HCII+/+ and
HCII+/– mice. Values were normalized by arbitrarily setting the measurement in
HCII+/+ mice without cuff injury to 1.0. Values are expressed as mean ± SEM. *
P < 0.05; **
P < 0.01.
n = 10 in each group.
