Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II–deficient mice
J. Clin. Invest. Ken-ichi Aihara, et al. 117:1514 doi:10.1172/JCI27095 [
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Figure 4Effect of HCII deficiency on hemostatic examinations. (
A) Plasma fibrinogen concentration, prothrombin time, and AT activity in
HCII+/+ (white bars) and
HCII+/– mice (black bars). Values are expressed as mean ± SEM.
n = 6–12 in each group. (
B) The left and middle panels show representative results of platelet aggregation analyzed by the screen filtration pressure method in
HCII+/+ and
HCII+/– mice. The platelet aggregation pressure of each reaction tube was determined as the pressure rate (percentage). For screen filtration pressure aggregometer study, the pressure rate was standardized using a grading curve produced by plotting 3 concentrations of ADP on the
x axis and pressure rate (percentage) on the
y axis. The concentration of ADP causing a 50% increase in pressure rate was calculated and applied as the platelet aggregatory threshold index (PATI) in
HCII+/+ (white bar) and
HCII+/– mice (black bar).
n = 6 in each group. Values are expressed as mean ± SEM. *
P < 0.05.
