Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung
J. Clin. Invest. 116:3 doi:10.1172/JCI27009 [Go to this article.]

Figure 1
LPS inhalation caused a significant recruitment of PMN into the BAL.

In CXCR2^–/– mice, PMN recruitment was completely abolished. In mice heterozygous for the CXCR2 allele (CXCR2^+/–), a reduction of ~50% was observed. Data are mean ± SD of n = 6 mice in each group. Cytospins of LPS-exposed BAL in CXCR2^+/+ and CXCR2^–/– mice are shown above the corresponding bars. *P < 0.05 versus CXCR2^+/+; ^#P < 0.05 versus no LPS.