Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice
J. Clin. Invest. John D. Belcher, et al. 116:808 doi:10.1172/JCI26857 [Go to this article.]

Figure 5
Further upregulation of HO-1 by hemin inhibits hypoxia/reoxygenation–induced increases in leukocyte-endothelium interactions. S+S-Antilles mice with an implanted DSFC were treated with either placebo (saline) or hemin injections (40 μmol/kg/d, i.p.) for 3 days. Twenty-four hours after the third injection, leukocyte rolling and adhesion were measured in the subcutaneous venules at base line in ambient air and again in the same venules after exposure of the mice to 1 hour of hypoxia (7% O₂/93% N₂) and 1 hour of reoxygenation in room air. Results are mean ± SEM percentage change in leukocyte rolling and adhesion after hypoxia/reoxygenation. n = 2 mice and a minimum of 20 venules per group. *P < 0.05, placebo versus hemin.