Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice
J. Clin. Invest. John D. Belcher, et al. 116:808 doi:10.1172/JCI26857 [Go to this article.]

Figure 4
CO and biliverdin inhibit stasis in sickle mice. S+S-Antilles mice with an implanted DSFC were either untreated or treated with inhaled CO (250 ppm CO in air for 1 hour per day) for 3 days or biliverdin injections (50 μmol/kg i.p. twice, at 16 hours and 2 hours, before hypoxia). Twenty-four hours after the third CO treatment or 2 hours after the second biliverdin injection, stasis was measured after 1 hour of hypoxia (7% O₂/93% N₂) and 1 hour of reoxygenation in room air. n = 3–10 mice and a minimum of 20 venules per mouse. *P < 0.05, untreated versus CO or biliverdin. The proportions of venules exhibiting stasis at each time point were compared using a z test.