Figure 3
Inhibition of hypothalamic CPT1A activity or expression decreases food intake.
(A) Schematic representation of the feeding experiments. (B and C) Daily changes in food intake and body weight induced by icv administration of 2 doses of the CPT1A inhibitor or of its inactive stereoisomer in SC and OF rats. (D and E) Arcuate CPT1 activity and CPT1A expression in arcuate nucleus of SC and OF rats treated with CPT1A-Ribo or vector. (F and G) Changes in food intake and body weight induced by icv administration of CPT1A-Ribo or vector in SC and OF rats. *P < 0.05 versus control and day 0.
