JCI - Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia

Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia

Tanya Tolmachova, Ross Anders, Magnus Abrink, Laurence Bugeon, Margaret J. Dallman, Clare E. Futter, José S. Ramalho, Felix Tonagel, Naoyuki Tanimoto, Mathias W. Seeliger, Clare Huxley, Miguel C. Seabra

Published in Volume 116, Issue 2

J Clin Invest. 2006; 116(2):386–394 doi:10.1172/JCI26617

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Figure 3

Ophthalmic and electroretinographic analysis of Chm mutant mouse eyes.

(A) Retinal SLO images from representative Chm mutant animals. The Chm alleles, MerCreMer (MCM) transgene, six3-Cre transgene, and TM induction (+TM) are indicated to the left of each set of panels. An equipment setting of 20° was used for a full view and of 10° for a more detailed view. The wavelengths shown are infrared (890 nm and 20°, IR20), green (514 nm and 20° or 10°, RF20 and RF10), and blue autofluorescence (488 nm with barrier at 500 nm and 10°, AF10). (B) Electroretinographic analysis showing a and b waves for the indicated strains of mice. Box and whisker plot of mutant mouse data (red) (whiskers 5% and 95% quantile, box 25–75% quantile, asterisk median) in comparison with respective control mouse data (black) (5% and 95% quantiles indicated by the lower and upper black lines, respectively, delimiting a 90% normal range). mcds, millicandela seconds.