Ravi Amaravadi, Craig B. Thompson
J Clin Invest.
2005;
115(10):2618–2624
doi:10.1172/JCI26273
This article Copyright © 2005, The American Society for Clinical Investigation
Abstract
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he Akt and Pim kinases are cytoplasmic serine/threonine kinases that control programmed cell death by phosphorylating substrates that regulate both apoptosis and cellular metabolism. The PI3K-dependent activation of the Akt kinases and the JAK/STAT–dependent induction of the Pim kinases are examples of partially overlapping survival kinase pathways. Pharmacological manipulation of such kinases could have a major impact on the treatment of a wide variety of human diseases including cancer, inflammatory disorders, and ischemic diseases.
