The latency-associated nuclear antigen of Kaposi sarcoma–associated herpesvirus induces B cell hyperplasia and lymphoma
J. Clin. Invest. Farnaz D. Fakhari, et al. 116:735 doi:10.1172/JCI26190 [
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Figure 5Anaplastic plasmacytoma in a LANA transgenic animal. (
A–
D) IgG-κ expression (surface and intracellular) in a lymphoma from LANA transgenic (
A and
C) and nontransgenic (
B and
D) littermates. (
E and
F) CXC-chemokine receptor 4 (CXCR4) for expression in LANA transgenic (
E) or control (
F) mice. Magnification, ×100 (
A,
B,
E, and
F); ×400 (
C and
D). All sections are counterstained blue with hematoxylin. (
G and
H) Flow cytometry analysis of the anaplastic plasmacytoma. (
I and
J) Flow cytometry analysis of spleen of a nontransgenic littermate. (
G and
I) Gates represent CD138
+B220
+CD27
– lymphoma cells at 16% frequency and normal spleen cells at 3% frequency. (
H and
J) Gates represent IgG-κ
+B220
–CD27
– lymphoma cells at 20% frequency and normal spleen cells at 2% frequency.
