Blocking the α4 integrin–paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site
J. Clin. Invest. Chloé C. Féral, et al. 116:715 doi:10.1172/JCI26091 [
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Figure 8The α4 integrin–paxillin interaction is required for optimal organogenesis of Peyer’s patches The number (
A) and size (
B) of intestinal Peyer’s patches in WT and α4(Y991A) mice are shown. Peyer’s patches were identified and enumerated by gross morphology. Peyer’s patch diameter was evaluated with a micrometer. Results shown are mean ± SEM of 6–8 mice. *
P = 0.014, 2-tailed Student’s
t test. (
C) Histology of Peyer’s patches from WT and α4(Y991A) is shown. Sections from paraffin embedded intestines were stained with H&E. Arrows indicate Peyer’s patches. Magnification, ×100. (
D) The percentage of T and B cells in Peyer’s patches from WT and α4(Y991A) is shown. Cells isolated from Peyer’s patches were stained with anti-B220 and anti-CD3 and analyzed by flow cytometry. Results are representative of 6–8 different mice.