Blocking the α4 integrin–paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site
J. Clin. Invest. Chloé C. Féral, et al. 116:715 doi:10.1172/JCI26091 [Go to this article.]

Figure 8
The α4 integrin–paxillin interaction is required for optimal organogenesis of Peyer’s patches The number (A) and size (B) of intestinal Peyer’s patches in WT and α4(Y991A) mice are shown. Peyer’s patches were identified and enumerated by gross morphology. Peyer’s patch diameter was evaluated with a micrometer. Results shown are mean ± SEM of 6–8 mice. *P = 0.014, 2-tailed Student’s t test. (C) Histology of Peyer’s patches from WT and α4(Y991A) is shown. Sections from paraffin embedded intestines were stained with H&E. Arrows indicate Peyer’s patches. Magnification, ×100. (D) The percentage of T and B cells in Peyer’s patches from WT and α4(Y991A) is shown. Cells isolated from Peyer’s patches were stained with anti-B220 and anti-CD3 and analyzed by flow cytometry. Results are representative of 6–8 different mice.