Blocking the α4 integrin–paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site
J. Clin. Invest. Chloé C. Féral, et al. 116:715 doi:10.1172/JCI26091 [
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Figure 7T cell–dependent and –independent humoral immune responses are not impaired by the disruption of the α4 integrin–paxillin interaction. WT and α4(Y991A) mice were immunized intraperitoneally with T cell–dependent antigen (TNP-KLH) and T cell–independent antigens (TNP-LPS and TNP-Ficoll) on day 0 and day 21. Anti-TNP IgM and IgG levels from preimmune serum and serum collected weekly after immunization were determined by enzyme-linked immunosorbent assay with TNP-OVA. Data shown are mean ± SEM of 3–4 mice.
