Blocking the α4 integrin–paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site
J. Clin. Invest. Chloé C. Féral, et al. 116:715 doi:10.1172/JCI26091 [Go to this article.]

Figure 5
Disruption of the α4 integrin–paxillin interaction does not interfere with T and B cell development in primary lymphoid organs. (A) The relative percentage of B220⁺ pro-, pre-, and immature B lymphocytes from bone marrow isolated from WT and α4(Y991A) mice between 6 and 8 weeks of age is shown. Flow cytometry was used to distinguish pro-B cells (B220⁺CD43⁺), pre-B cells (B220⁺IgM^–IgD^–), and immature B cells (B220⁺IgM⁺IgD^–). Results are mean ± SEM from 6–8 mice. (B) The percentage of thymocytes expressing CD4/CD8 is shown. Thymocytes were collected from WT and α4(Y991A) mice and analyzed for CD4 and CD8 expression by flow cytometry. Results are representative of 6–8 different mice.