Blocking the α4 integrin–paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site
J. Clin. Invest. Chloé C. Féral, et al. 116:715 doi:10.1172/JCI26091 [Go to this article.]

Figure 4
Hematopoiesis in WT and α4(Y991A) mice. (A) Peripheral blood monocyte counts are shown, the only blood cell type that displayed a statistically significant difference between the 2 strains of mice. *P = 0.041, 2-tailed Student’s t test. (B) The number of BFU-E–, GM-CFU–, and CFU-Mk–derived colonies from WT and α4(Y991A) mice is shown as the mean ± SEM of colonies of each type obtained from 1 × 10⁵ marrow cells from each of 4 mice. A representative example of 3 separate experiments giving essentially identical results is shown. The mean number of colony-forming cells was not statistically different (Student’s t test). (C) The number of GM-CFU derived from the marrow or spleens of lethally irradiated recipient mice following intraocular injection of 2 × 10⁷ marrow cells is shown; the data shown represent the mean ± SEM of results from 4 mice in each group. The number of progenitors that lodged in the marrow (per 1 × 10⁵ cells plated) and spleens (per 2 × 10⁵ cells plated) was not significantly different (2-tailed Student’s t test).