Thyrotropin receptor–associated diseases: from adenomata to Graves disease
J. Clin. Invest. Terry F. Davies, et al. 115:1972 doi:10.1172/JCI26031 [Go to this article.]

Figure 1
TSHR structure. This computer model of the TSHR shows the 7 TMDs (spirals) embedded within the plasma membrane and a short cytoplasmic tail, which together make up the β/B subunit. The unique 50-aa–long cleaved region (about 316–366 aa) is shown in gray. Forming a long array, the 9 LRRs, each consisting of 20–24 aa, are depicted as spirals (α helices and β pleated sheets) on the ectodomain of the receptor and make up the major portion of the α/A subunit. The LRRs have a characteristic horseshoe shape with a concave inner surface. C, C-terminus; N, N-terminus. Figure adapted with permission from Thyroid (28).