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Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight
Michael Rosenbaum, Rochelle Goldsmith, Daniel Bloomfield, Anthony Magnano, Louis Weimer, Steven Heymsfield, Dympna Gallagher, Laurel Mayer, Ellen Murphy, Rudolph L. Leibel
Published in Volume 115, Issue 12
J Clin Invest. 2005; 115(12):3579–3586 doi:10.1172/JCI25977
This article Copyright © 2005, The American Society for Clinical Investigation
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Figure 6

Autonomic function. Percent change (mean ± SEM) from values at Wtinitial of autonomic nervous system tone. Administration of leptin to weight-reduced subjects reversed the significant declines in one 24-hour urinary epinephrine excretion and SNS tone (measured by heart rate analysis during serial pharmacological blockade), which are associated with maintenance of a 10% reduced body weight. No effect of leptin was noted on urinary dopamine excretion, on the significant decline in urinary norepinpehrine excretion, or on the significant increase in parasympathetic tone associated with maintenance of a 10% reduced body weight. Mean ± SEM values at each weight plateau are presented in Supplemental Table 1. *P < 0.05 versus 0; †P < 0.05 versus Wt–10%.

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