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Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight
Michael Rosenbaum, Rochelle Goldsmith, Daniel Bloomfield, Anthony Magnano, Louis Weimer, Steven Heymsfield, Dympna Gallagher, Laurel Mayer, Ellen Murphy, Rudolph L. Leibel
Published in Volume 115, Issue 12
J Clin Invest. 2005; 115(12):3579–3586 doi:10.1172/JCI25977
This article Copyright © 2005, The American Society for Clinical Investigation
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Figure 4

Energy expenditure and skeletal muscle. Percent change (mean ± SEM) from values at Wtinitial of energy expenditure, skeletal muscle work efficiency, and fuel utilization. Administration of leptin to weight-reduced subjects reversed the significant decline in TEE and NREE associated with maintenance of a 10% reduced body weight. Effects of weight loss and exogenous leptin on skeletal muscle gross mechanical work efficiency (kcal/min energy expended above resting per kcal/min work generated) and fuel utilization (derived from RQ; ref. 87) were only evident at low levels of work (bicycling to generate 10 W of power). Mean ± SEM values at each weight plateau are presented in Supplemental Table 1, and individual values are presented in Supplemental Figure 1. *P < 0.05 versus 0; †P < 0.05 versus Wt–10%. GME, gross mechanical efficiency.

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