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Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight
Michael Rosenbaum, Rochelle Goldsmith, Daniel Bloomfield, Anthony Magnano, Louis Weimer, Steven Heymsfield, Dympna Gallagher, Laurel Mayer, Ellen Murphy, Rudolph L. Leibel
Published in Volume 115, Issue 12
J Clin Invest. 2005; 115(12):3579–3586 doi:10.1172/JCI25977
This article Copyright © 2005, The American Society for Clinical Investigation
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Figure 2

Effects of weight loss and leptin administration on circulating leptin concentrations. (A) 8 am plasma leptin concentrations at Wtinitial, Wt–10%, and Wt–10%lep. Circulating leptin concentrations were significantly lower at Wt–10%, than at Wtinitial or at Wt–10%lep. (B) Percent changes (mean ± SEM) from Wtinitial values in plasma leptin concentrations at Wt–10% and Wt–10%lep. *P < 0.05 compared with 0.

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