Role of ERK1/2 MAPK in IL-13–induced inflammation.
BAL fluids and lungs were obtained from IL-13– and CC10–rtTA–IL-13 Tg+ (IL-13+) mice. (A) BAL-fluid cellularity of mice treated with PD or vehicle control (veh). (B) BAL-fluid cellularity of IL-13+ mice with and without dnMEK1. (C) MBP immunostaining and morphometric eosinophil quantification were used in comparing lungs from IL-13– and IL-13+ mice after PD administration or with and without dnMEK1. Data are expressed as mean ± SEM and are representative of n = 4–16 for each group. *P < 0.05 compared with IL-13+.