Immunopathogenesis and therapy of cutaneous T cell lymphoma
J. Clin. Invest. Ellen J. Kim, et al. 115:798 doi:10.1172/JCI24826 [Go to this article.]

Figure 3
The skin microenvironment in MF progression. (A) Normal skin showing resident Langerhans cells in the epidermis and skin-homing T cells in the dermis and circulation. (B) Patch and plaque MF in which the CD4⁺ malignant T cells home to the epidermis and collect around Langerhans cells. Of note, in these stages, the epidermal and dermal infiltrate frequently have abundant CD8⁺ T cells as part of the host immune response. (C) Tumor MF in which the tumor occupies the dermis and subcutaneous tissue and is comprised of primarily malignant T cells and few CD8⁺ T cells. (D) Erythrodermic MF and SS with detectable circulating malignant T cells that elaborate Th2 cytokines that affect CD8⁺ T cell, NK cell, and DC numbers and function, and consequently, the host immune response.