Yakov Chudnovsky, Paul A. Khavari, Amy E. Adams
J Clin Invest.
2005;
115(4):813–824
doi:10.1172/JCI24808
This article Copyright © 2005, The American Society for Clinical Investigation
Abstract
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Supplemental material
M
elanoma is a cancer of the neural crest–derived cells that provide pigmentation to skin and other tissues. Over the past 4 decades, the incidence of melanoma has increased more rapidly than that of any other malignancy in the United States. No current treatments substantially enhance patient survival once metastasis has occurred. This review focuses on recent insights into melanoma genetics and new therapeutic approaches being developed based on these advances.
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