Attenuated liver fibrosis in the absence
of B cells
J. Clin. Invest. Tatiana I. Novobrantseva, et al. 115:3072 doi:10.1172/JCI24798 [
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Figure 3B cell–deficient mice have altered kinetics of response to a CCl
4-induced liver injury. Mice of the genotype indicated were gavaged once with 1.75 ml/kg of CCl
4 or with mineral oil. Either 1, 3, or 5 days after treatment, mice were sacrificed, and immunohistochemical analyses of liver sections were performed. Magnification for apoptotic cell–specific TUNEL, macrophage-specific F4/80, and myofibroblast-specific α-SMA stainings, ×100.
