Attenuated liver fibrosis in the absence of B cells
J. Clin. Invest. Tatiana I. Novobrantseva, et al. 115:3072 doi:10.1172/JCI24798 [Go to this article.]

Figure 2
The degree of liver fibrogenesis is proportionate to B cell numbers. Mice were gavaged with 3.5 ml/kg (A and B and C, left panel) or 1.75 ml/kg (C, right panel, and D) of CCl₄ or mineral oil. Each plot represents 1 experiment. (A) J_H–/– and BALB/c WT control mice were bled 24 hours after a single CCl₄ or oil administration, and ALT levels were measured. A representative experiment out of 3 is shown. (B–D) One week after the sixth weekly treatment of oil or CCl₄, mice were sacrificed, and collagen-specific Sirius red staining of liver sections was performed to quantify interstitial collagen deposition in J_H–/– and WT BALB/c mice (C) or in WT C57BL/6 and BAFF-Tg mice (D). Magnification, ×50. In each case, a representative experiment out of at least 2 is shown. A column of dots represents a series of sections from 1 animal; mean values are depicted as red bars.