Attenuated liver fibrosis in the absence of B cells
J. Clin. Invest. Tatiana I. Novobrantseva, et al. 115:3072 doi:10.1172/JCI24798 [Go to this article.]

Figure 1
Phenotypic and functional characterization of IHB cells. (A) Lymphocytes defined by their scatter (51) were stained with anti-IgD (x axis) and anti-IgM (y axis). Percentages of IgM⁺ and IgD⁺ cells are shown next to the gate. (B) The histograms compare the levels of CD21, CD23, and CD5 on CD19⁺ B cells from spleen, blood, PC, and liver. (C) Viability of CD19⁺ B cells from liver and spleen was assessed by staining with the DNA intercalating reagent 7AAD and annexin V (AnV); double-negative cells are viable. (D) Residual CFSE fluorescence intensity and CD86 levels in CFSE-labeled B cells from liver (upper panels) and spleen (lower panels) after 3.5 days of activation in the presence of different stimuli noted. NS, no stimulation.