Disease-related phenotypes in a Drosophila model of hereditary spastic paraplegia are ameliorated by treatment with vinblastine
J. Clin. Invest. Genny Orso, et al. 115:3026 doi:10.1172/JCI24694 [
Go to this article.]
Figure 3Expression of
Dspastin K467R in the
Drosophila eye opposes the phenotypic effects of wild-type
Dspastin expression. (
A) Wild-type
Drosophila eye. (
B) Eyes expressing low levels of UAS-
Dspastin under the control of GMR-Gal4 displayed a moderate rough phenotype. (
C) Expression of UAS-
Dspastin-K467R alone had no phenotypic consequences in the eye. (
D) Simultaneous expression of both constructs resulted in a practically normal external morphology, suggesting that
Dspastin K467R suppresses the rough eye phenotype caused by UAS-
Dspastin expression.
