Disease-related phenotypes in a Drosophila model of hereditary spastic paraplegia are ameliorated by treatment with vinblastine
J. Clin. Invest. Genny Orso, et al. 115:3026 doi:10.1172/JCI24694 [Go to this article.]

Figure 2
Reducing Dspastin expression produces age-dependent neurodegeneration. (A) One-day-old fly with transgenic expression of Dspastin RNAi showed no sign of neurodegeneration. (B) Twenty-day-old fly with transgenic expression of Dspastin RNAi had numerous vacuoles in the cortex and neuropil (arrows). (C) Twenty-day-old control fly showed no evidence of neurodegeneration. (D) Degenerating cells were TUNEL positive (arrows). (E) No TUNEL-positive cells were present in age-matched control flies. Control genotypes were as follows: Elav-Gal4/+ and UAS-Dspastin-RNAi/+. The experimental genotype used was Elav-Gal4/+;UAS-Dspastin-RNAi/+.