To live or die: a critical decision for the lung
J. Clin. Invest. G.R. Scott Budinger, et al. 115:828 doi:10.1172/JCI24681 [
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Figure 1Schematic representation of the cell-death pathways activated by exposure to hyperoxia. The Bcl-2 family of proteins is a group that contains 1 BH domain (BH3) or 3 BH domains (BH1–BH3), both of which induce cell death, and also contains 4 BH domains (BH1–BH4), which protect against cell death (see text for details). In this issue of the
JCI, He et al. (
9) report that IL-11 induces expression of the antiapoptotic Bcl-2–related protein A1, which is required for IL-11–induced protection against hyperoxia-induced lung injury. IAP, inhibitor of apoptosis protein; IL-11R, IL-11 receptor.
