Brian L. Stauffer, John P. Konhilas, Elizabeth D. Luczak, Leslie A. Leinwand
J Clin Invest.
2006;
116(1):209–216
doi:10.1172/JCI24676
This article Copyright © 2006, The American Society for Clinical Investigation
Abstract
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e report that dietary modification from a soy-based diet to a casein-based diet radically improves disease indicators and cardiac function in a transgenic mouse model of hypertrophic cardiomyopathy. On a soy diet, males with a mutation in the α-myosin heavy chain gene progress to dilation and heart failure. However, males fed a casein diet no longer deteriorate to severe, dilated cardiomyopathy. Remarkably, their LV size and contractile function are preserved. Further, this diet prevents a number of pathologic indicators in males, including fibrosis, induction of β-myosin heavy chain, inactivation of glycogen synthase kinase 3β (GSK3β), and caspase-3 activation.
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