Figure 1
Cardiac growth due to transgene expression is modified by sex and diet at 8 months of age.
(A) VW normalized to body growth, assessed by TL. *Significant transgene effect with each sex and diet combination (P < 0.005 for each). †Significant sex effect by diet in both WT and HCM mice (P < 0.0001). #Significant diet effect (P < 0.05) between groups except in WT males. (B) There is a diet-dependent difference in the degree of hypertrophy in the male mice while there is no diet-dependent difference in the female animals. ΧP < 0.01 versus male casein. n = 21–35 in each group. HCM, transgenic HCM mice. Mean ± SEM.
