Pertussis toxin inhibits neutrophil recruitment to delay antibody-mediated clearance
of Bordetella pertussis
J. Clin. Invest. Girish S. Kirimanjeswara, et al. 115:3594 doi:10.1172/JCI24609 [
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Figure 6FcγRs and neutrophils are required for serum antibody–mediated clearance of
B. pertussisΔ
PTx. (
A) C57BL/6 or FcγR
–/– mice were inoculated with 5 × 10
5 CFU of
B. pertussisΔ
PTx and adoptively transferred 200 μl of either naive or convalescent-phase serum. (
B) C57BL/6 mice also received either PBS or 1 mg of mAb RB6-8C5 (
n = 4 per group). Lungs were harvested on the indicated days, and bacteria were enumerated and expressed as mean ± SEM. Dotted line denotes limit of detection.
n = 4 per group. *
P < 0.001; **
P < 0.05.
