Pertussis toxin inhibits neutrophil recruitment to delay antibody-mediated clearance
of Bordetella pertussis
J. Clin. Invest. Girish S. Kirimanjeswara, et al. 115:3594 doi:10.1172/JCI24609 [
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Figure 5PTx inhibits recruitment of neutrophils to the lungs. C57BL/6 mice were inoculated with 5 × 10
5 CFU of
B. pertussis (circles) or
B. pertussisΔ
PTx (squares). Mice were sacrificed on the indicated days and their lungs perfused with 5 ml cold PBS, and total leukocytes per whole lung were enumerated. Individual cell types were determined by modified Giemsa staining of cells.
n = 4 per group. *
P < 0.001; **
P < 0.05.
