Pertussis toxin inhibits neutrophil recruitment to delay antibody-mediated clearance
of Bordetella pertussis
J. Clin. Invest. Girish S. Kirimanjeswara, et al. 115:3594 doi:10.1172/JCI24609 [
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Figure 3Depletion of neutrophils abrogates antibody-mediated clearance of
B. pertussis. C57BL/6 mice were treated with PBS or 1 mg of neutrophil-depleting mAb RB6-8C5. Mice were subsequently inoculated with 5 × 10
5 CFU of
B. pertussis and adoptively transferred 200 μl of either naive (white bars) or convalescent-phase serum (black bars). On day 14 after inoculation, mice were sacrificed, and bacteria in the lungs were enumerated and expressed as geometric mean ± SEM. Dotted line denotes limit of detection.
n = 4 per group. *
P < 0.001.
