The role of insulin receptor substrate 2 in hypothalamic and β cell function
J. Clin. Invest. Agharul I. Choudhury, et al. 115:940 doi:10.1172/JCI24445 [Go to this article.]

Figure 5
Analysis of recombination and duct-marker expression in islets from RIPCreIrs2KOZEG mice. (A–D) Immunofluorescence staining for insulin (red) in islets from 4-week-old (A and B) and 9-month-old (C and D) RIPCreIrs2KOZEG mice stained for DNA (DAPI, blue). White arrows indicate β cells that do not express GFP and have not undergone recombination. Many cells in the 9-month-old islet do not express GFP. (E–G) Labeling of ducts with DBA in islets from 9-month-old RIPCreIrs2KOZEG mice stained blue for either DNA (E and F) or insulin (G). No duct marker is expressed in GFP-negative β cells. Scale bars: 100 μm.